呼吸器病学（気管支喘息・COPDなどの気道炎症性疾患）
臨床アレルギー学（食物アレルギー・薬剤アレルギーなど）

気道炎症の制御
炎症のエピジェネティクス
アレルギー機序の解明

【主要論文】

1. To M, Tsuzuki R, Katsube O, Yamawaki S, Soeda S, Kono Y, Honda N, Kano I, Haruki K, To Y. Persistent asthma from childhood to adulthood presents a distinct phenotype of adult asthma. JACI in practice. 8(6):1921-1927. 2020.
2. To M, Tsuzuki R, Katsube O, Yamawaki S, Soeda S, Yuta Kono, Honda N, Kano I, Haruki K, To Y. A difference in impacts of comorbidity of allergic rhinitis on asthma symptoms between obese and non-obese patients. Respir Invest. 57(3):286-289. 2019.
3. To M, Hitani A, Kono Y, Honda N, Kano I, Haruki K, To Y. Obsity-associated severe asthma in an adult Japanese population. Respir Invest. 56(6):440-447. 2018.
4. To M, Kono Y, Ogura N, Mikami S, Honda N, Hitani A, Kano I, Haruki K,To Y. Obesity-related systemic oxidative stress: An important factor of poor asthma control Allergology International.67(1):147-149. 2018.
5. Kono Y, Soeda S, Okada Y, Hara H, Araki K, To M, To Y. A surrogate marker of airway hyperresponsiveness in patients with bronchial asthma. Allergology International. 63(3):487-488. 2014.
6. Kono Y, Tsushima K, Yamaguchi K, Kurita N, Soeda S, Fujiwara A, Sugiyama S, Togashi Y, Kasagi S, To M, To Y, Setoguchi Y. The utility of galactomannan antigen in the bronchial washing and serum for diagnosing pulmonary aspergillosis. Respir Med. 107(7):1094-1100. 2013.
7. To Y, Kinoshita M, Lee SH, Hang LW, Ichinose M, Fukuchi Y, Kitawaki T, Okino N, Prasad N, Lawrence D, Kramer B. Assesing efficacy of Indacaterol in moderate and severe COPD patients: A 12-week study in an asian population. Respir Med. 106(12):1715-1721. 2012.
8. Yomota M, Amano I, Horita N, Takezawa T, Arai T, To M, To Y. Serum immunoglobulin G is a marker for the risk of oppotunistic infection in steroid dependent severe asthmatic patients. Internal Med. 51(19) :2715-2719. 2012.
9. Horita N, To M, Araki K, Haruki K, To Y. Risk factors of local oropharyngeal and laryngeal adverse effects from use of single inhaled corticosteroids and long-acting beta agonists. Allergology International. 61(4): 583-588. 2012.
10. Horita N, Akahane M, Okada Y, Kobayashi Y, Arai T, Amano I, Takezawa T, To M,To Y. Tacrolimus and steroid treatment for acute exacerbation of interstitial pulmonary fibrosis. Internal Med. 50(3):189-195. 2011.
11. Rossios C & To Y, Osoata G, Ito M, Barnes PJ, Ito K. Corticosteroid insensitivity is reversed by formoterol via phosphoinositide 3 kinase inhibition. Br J Pharmacol 167(4):775-86. 2012.
12. Rossios C & To Y, To M, Ito M, Barnes PJ, Adcock IM, Johnson M, Ito K. Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells. Eur J Pharmacol. 670(1):244-251 2012.
13. Mercado N & To Y, Kobayashi Y, Adcock IM, Barnes PJ, Ito K. p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol. 80(6):1128-35. 2011.
14. Mercado N & To Y, Ito K, Barnes PJ.Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ. J Pharmacol Exp Ther. 337(2):465-70. 2011.
15. To Y & Ito K, Kizawa Y, Failla M, Ito M, Kusama T, Elliott WM, Hogg JC, Adcock IM, Barnes PJ.　Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.　Am J Respir Crit Care Med. 182(7):897-904. 2010.
16. Enesa K, Ito K, Luong le A, Thorbjornsen I, Phua C, To Y, Dean J, Haskard DO, Boyle J, Adcock I, Evans PC.　Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.　J Biol Chem. 283(27):18582-90. 2008.
17. Nagatani K, Dohi M, To Y, Tanaka R, Okunishi K, Nakagome K, Sagawa K, Tanno Y, Komagata Y, Yamamoto K. Splenic dendritic cells induced by oral antigen administration are important for the transfer of oral tolerance in an experimental model of asthma. J Immunol. 176(3):1481-9.2006.
18. Nakagome K, Dohi M, Okunishi K, To Y, Sato A, Komagata Y, Nagatani K, Tanaka R, Yamamoto K. Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting. Respir Res. 6:46.2005.
19. To M, To Y, Yamada H, Ogawa C, Otomo M, Suzuki N, Sano Y. Influence of inhaled corticosteroids on community-acquired pneumonia in patients with bronchial asthma. Intern Med. 43(8):674-8. 2004.
20. Sano Y, Suzuki N, Yamada H, To Y, Ogawa C, Ohta K, Adachi M. Effects of suplatast tosilate on allergic eosinophilic airway inflammation in patients with mild asthma. J Allergy Clin Immunol. 111(5):958-66.2003.
21. To Y, Dohi M, Matsumoto K, Tanaka R, Sato A, Nakagome K, Nakamura T, Yamamoto K. A two-way interaction between hepatocyte growth factor and interleukin-6 in tissue invasion of lung cancer cell line Am J Respir Cell Mol Biol. 27(2):220-6.2002.
22. To Y, Koshino T, To M, Kudo K, Sano Y, Ito K. “Effect of short-course steroid treatment for airway inflammation in patients with asthma.” Allergology International. 51: 85-91, 2002.
23. To Y, Dohi M, Tanaka R, Sato A, Nakagome K, Yamamoto K. Early interleukin 4-dependent response can induce airway hyperreactivity before development of airway inflammation in a mouse model of asthma. Lab Invest. 81(10):1385-96.2001.
24. Dohi M, Tsukamoto S, Nagahori T, Shinagawa K, Saitoh K, Tanaka Y, Kobayashi S, Tanaka R, To Y, Yamamoto K. Noninvasive system for evaluating the allergen-specific airway response in a murine model of asthma.　Lab Invest. 79(12):1559-71.1999.

1991：佐賀医科大学（現・佐賀大学）医学部医学科　卒
2002：東京大学大学院医学系研究科内科学専攻　卒
医学博士号

【職歴】
1991-1993 国立国際医療センター内科　臨床研修医
1993-1996 国立国際医療センター呼吸器科　レジデント
1996-1998 同愛記念病院アレルギー呼吸器科　医員
1998-2002 東京大学大学院医学系研究科内科学専攻
2002-2003 東京都立駒込病院アレルギー膠原病科　医師
2003-2007 英国国立心臓肺研究所（ロンドン）気道疾患部門留学
2008-2020 同愛記念病院アレルギー呼吸器科　部長
2020-         国際医療福祉大学医学部呼吸器内科学　教授（現在に至る）

【学会】
日本内科学会　認定内科専門医・臨床研修指導医
日本呼吸器学会　専門医・指導医
日本アレルギー学会　専門医・指導医・代議員・広報委員会委員・教育研修委員会委員・新専門医制度対策検討特別委員会
日本臨床検査医学会
日本感染症学会
Infection Control Doctor
東京都身体障碍者指定医（呼吸器機能障害）

気管支喘息・COPDなどの気道炎症を中心に基礎研究・臨床研究を多数行ってきました。現在も日常臨床で出会った症例からいろいろなことを学び、素朴な疑問を掘り下げてゆく手法で研究テーマを決定・実行しております。これから医師となるみなさんも、子供のころに感じていた「なぜ？」「どうして？」という心をこれからも大切にして学問としての医学をともに発展させてゆきましょう。エビデンスはただ読んで学ぶだけのものではありません。わたしたち自身が基礎・臨床のさまざまな研究を論文として発表することで、自らエビデンスを造ってゆくのです。自分が書いた論文がUpToDate™に引用されるなんて、痛快なことだと思いませんか？その気概がある学生さん・先生方は、是非お声をお掛けください。

【TEL】03-3451-8121
【FAX】03-3454-0067
【E-Mail】y.to@iuhw.ac.jp