消化器内科学

【researchmap】
https://researchmap.jp/osawa-gif

1. Osawa Y, Kawai H, Tsunoda T, Komatsu H, Okawara M, Tsutsui Y, Yoshida Y, Yoshikawa S, Mori T, Yamazoe T, Yoshio S, Oide T, Inui A, KantoT. Cluster of differentiation 44 promotes liver fibrosis and serves as a biomarker in congestive hepatopathy. Hepatol Commun. 5, 1437, 2021.
2. Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Hishima T, Saibara T, Shibasaki F, Kohara M, Kimura K. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine, 2, 1751–1758, 2015.
3. Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O. Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. J Clin Invest. 123, 834-843, 2013.
4. Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M. L-Tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 286, 34800-34808, 2011.
5. Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology. 51, 237-245, 2010.
6. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. TLR4 enhances TGF-β signaling and hepatic fibrosis. Nat Med. 13, 1324-1332, 2007.
7. Osawa Y, Hannun, YA, Proia RL, Brenner DA. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 42, 1320-1328, 2005.

岐阜大学医学部卒業、同大学院医学研究科修了・博士（医学）

米国コロンビア大学内科学教室留学。岐阜大学医学部医学科助教、講師、東京都立駒込病院肝臓内科医長、国立国際医療研究センター国府台病院消化器・肝臓内科室医長。

日本内科学会総合内科専門医、日本肝臓学会認定肝臓専門医・指導医、日本消化器病学会認定消化器病専門医・指導医、日本消化器内視鏡学会認定消化器内視鏡専門医・指導医、日本ヘリコバクター学会ピロリ菌感染症認定医