医療福祉の多彩なエキスパートを育てる。
国際医療福祉大学
INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE

成田キャンパス

成田キャンパス
薬理学教室

薬理学教室

教室紹介

業績

業績 Publications

  1. Marumo T, Yoshida N, Inoue N, Yamanouchi M, Ubara Y, Urakami S, Fujii T, Takazawa Y, Ohashi K, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Nagae G, Fujimoto M, Arai E, Kanai Y, Hoshino J, Fujita T:
    Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes
    Am J Physiol Renal Physiol 327: F397-F411, 2024

    ※詳細は学科トピックス「薬理学教室研究成果　糖尿病性腎症で生じる尿細管のDNAメチル化異常を明らかに」をご覧ください。

  2. Takenaka T, Hasan A, Marumo T, Inoue T, Miyazaki T, Suzuki H, Kurosaki Y, Ishii N, Nishiyama A, Hayashi M:
    Klotho supplementation reverses renal dysfunction and interstitial fibrosis in remnant kidney.
    Kidney Blood Press Res. 48 (1), 326-337, 2023
  3. Hirohama D, Nishimoto M, Ayuzawa N, Kawarazaki W, Fujii W, Oba S, Shibata S, Marumo T, Fujita T: Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice. Hypertension. 2021; 78:82-93.
  4. Takenaka T, Hasan A, Marumo T, Kobori H, Inoue T, Miyazaki T, Suzuki H, Nishiyama A, Ishii N, Hayashi M: Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy. J Hypertens. 2021; 39:1567-1576.
  5. Rahman A, Matsuyama M, Ebihara A, Shibayama Y, Hasan AU, Nakagami H, Suzuki F, Sun J, Kobayashi T, Hayashi H, Nakano D, Kobara H, Masaki T, Nishiyama A. Antiproliferative effects of monoclonal antibodies against (pro)renin receptor in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2020; 19(9):1844-1855. doi: 10.1158/1535-7163.
  6. Marumo T, Hoshino J, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Yamanouchi M, Ubara Y, Okaneya T, Fujii T, Yuki K, Atsumi Y, Sato A, Arai E, Kanai Y, Shimosawa T, Fujita T: Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes. BMJ Open Diabetes Res Care. 2020; 8 (1), e001501.
  7. Hirohama D, Kawarazaki W, Nishimoto M, Ayuzawa N, Marumo T, Shibata S, Fujita T: PGI 2 analog attenuates salt-induced renal injury through the inhibition of inflammation and rac1-MR activation. Int J Mol Sci. 2020, 21, 12, 4433.
  8. Kawarazaki W, Mizuno R, Nishimoto M, Ayuzawa N, Hirohama D, Ueda K, Kawakami-Mori F, Oba S, Marumo T, Fujita T: Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency. J Clin Invest. 2020; 130 (8), 4152-4166.
  9. Ayuzawa N, Nishimoto M, Ueda K, Hirohama D, Kawarazaki W, Shimosawa T, Marumo T, Fujita T: Two mineralocorticoid-receptor-mediated mechanisms of pendrin activation in distal nephrons. J Am Soc Nephrol. 2020; 31:748-764.
  10. Rahman A, Hasan AU, Kobori H. Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin-angiotensin system. Hypertens Res. 2019; 42(6): 920-923
  11. Hasan AU, Rahman A, Kobori H. Interactions between Host PPARs and Gut Microbiota in Health and Disease. Int J Mol Sci. 2019; 17:20(2). pii: E387
  12. Nishimoto M, Ohtsu H, Marumo T, Kawarazaki W, Ayuzawa N, Ueda K, Hirohama D, Kawakami-Mori F, Shibata S, Nagase M, Isshiki M, Oba S, Shimosawa T, Fujita T. Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in NON-diabetic hypertension: A SUB-ANALYSIS of EVALUATE STUDY. Hypertens Res. 2019; 42(4); 514-521
  13. Hasan AU, Ohmori K, Hashimoto T, Kamitori K, Yamaguchi F, Rahman A, Tokuda M, Kobori H. PPARγ activation mitigates glucocorticoid receptor-induced excessive lipolysis in adipocytes via homeostatic crosstalk. J Cell Biochem. 2018; 119(6): 4627-4635
  14. Rahman A, Hasan AU, Nishiyama A, Kobori H. Altered circadian timing system-mediated non-dipping pattern of blood pressure and associated cardiovascular disorders in metabolic and kidney diseases. Int J Mol Sci. 2018; 19(2). pii: E400
  15. Watanabe A, Marumo T, Kawarazaki W, Nishimoto M, Ayuzawa N, Ueda K, Hirohama D, Tanaka T, Yagi S, Ota S, Nagae G, Aburatani H, Kumagai H, Fujita T. Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney. Am J Physiol Renal Physiol. 2018; 314: F551-F560
  16. Oba S, Ayuzawa N, Nishimoto M, Kawarazaki W, Ueda K, Hirohama D, Kawakami-Mori F, Shimosawa T, Marumo T, Fujita T. Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells. Sci Rep. 2018; 8: 16338
  17. Kawakami-Mori F, Nishimoto M, Reheman L, Kawarazaki W, Ayuzawa N, Ueda K, Hirohama D, Kohno D, Oba M, Shimosawa T, Marumo T, Fujita T. Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal programmed hypertension. JCI Insight. 2018; 3(21): e95625
  18. Hirohama D, Ayuzawa N, Ueda K, Nishimoto M, Kawarazaki W, Watanabe A, Shimosawa T, Marumo T, Shibata S, Fujita T. Aldosterone is essential for angiotensin II-induced upregulation of pendrin. J Am Soc Nephrol. 2018; 29: 57-68
  19. Murase S, Shiiya T, Higuchi H. Neuropeptide Y Y5 receptor localization in mouse central nervous system. Brain Research. 2017; 1655: 216-232
  20. Ueda K, Nishimoto M, Hirohama D, Ayuzawa N, Kawarazaki W, Watanabe A, Shimosawa T, Loffing J, Zhang MZ, Marumo T, Fujita T. Renal dysfunction induced by kidney-specific gene deletion of Hsd11b2 as a primary cause of salt-dependent hypertension. Hypertension. 2017; 70: 111-118
  21. Marumo T, Yagi S, Kawarazaki W, Nishimoto M, Ayuzawa N, Watanabe A, Ueda K, Hirahashi J, Hishikawa K, Sakurai H, Shiota K, Fujita T. Diabetes induces aberrant DNA methylation in the proximal tubules of the kidney. J Am Soc Nephrol. 2015; 26: 2388-2397
  22. Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T. Epigenetic modulation of the renal beta-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med. 2011; 17: 573-580
  23. Ishihara Y, Ohmori K, Mizukawa M, Hasan AU, Noma T, Kohno M. Beneficial direct adipotropic actions of pitavastatin in vitro and their manifestations in obese mice. Atherosclerosis. 2010; 212(1): 131-138
  24. Murase S, Cho C, White JM, Horwitz AF. ADAM2 promotes migration of neuroblasts in the rostral migratory stream to the olfactory bulb. European Journal of Neuroscience, 2008; 27(7): 1585-1595
  25. Carbonell WS, Murase S, Horwitz AF, Mandell JW. Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: An in situ time-lapse confocal imaging study. Journal of Neuroscience, 2005; 25(30): 7040-7047
  26. Murase S, Horwitz AF. Directions in cell migration along the rostral migratory stream: The pathway for migration in the brain. Current Topics in Developmental Biology, 2004; 61: 135-152
  27. Murase S, Horwitz AF. Deleted in colorectal carcinoma and differentially expressed integrins mediate the directional migration of neural precursors in the rostral migratory stream. Journal of Neuroscience, 2002; 22(9): 3568-3579
  28. 丸茂丈史　腎臓病の進展に関わるエピジェネティクス. 医学のあゆみ, 2020; 272(1): 75-79
  29. 丸茂丈史　代謝疾患とエピゲノム. 遺伝子医学, 2020; 10(1): 49-52
  30. 丸茂丈史　【DKDの基礎】エピジェネティック異常. 腎と透析, 2018; 84(2): 185-189
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