成田キャンパス

医学部

DEPARTMENT OF MEDICINE

教員紹介

教授 澁田 達史

  • 専門分野
    • 麻酔薬理、小児麻酔、神経麻酔
  • 研究テーマ
    • 麻酔薬の中枢神経系における保護作用、小児期における麻酔薬の神経毒性
  • 研究実績

    【researchmap】
    https://researchmap.jp/read0076646


    1. Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats. Satoshi Shibuta, Takashi Mashimo, Akitoshi Ohara, Ping Zhang and Ikuto Yoshiya. Neurosci Lett 187: 103-106, 1995
    2. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. Satoshi Shibuta, Takashi Mashimo, Ping Zhang, Akitoshi Ohara and Ikuto Yoshiya J Neurol Sci 141: 1-5 1996
    3. Cardiovascular Effects of an Ultra-Short-Acting Nitric Oxide-Releasing Compound, Zwitterionic Diamine/NO Adduct, in dogs. Ping Zhang, Akitoshi Ohara, Takashi Mashimo, Jianhuna Sun, Satoshi Shibuta, Koji Takada, Hiroaki Kosaka, Masaru Terada and Ikuto Yoshiya. Circulation 94: 2235-2240 1996
    4. A comparative study of the antinociceptive action of xenon and nitrous oxide in rats. Akitoshi Ohara, Takashi Mashimo, Ping Zhang, Yoshimi Inagaki, Satoshi Shibuta and Ikuto Yoshiya Anesth Analg 85: 931-936 1997
    5. Nitric oxide-induced cytotoxicity attenuation by thiopentone sodium but not pentobarbitone sodium in primary brain cultures. Satoshi Shibuta, Jun Kosaka, Takashi Mashimo, Yutaka Fukuda and Ikuto Yoshiya. British Journal of Pharmacology 124: 804-810 1998
    6. Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in he rat neuropathic pain model. Takaya Inoue, Takashi Mashimo, Masahiko Shibata, Satoshi Shibuta and Ikuto Yoshiya. Brain Research 792: 263-270 1998
    7. The effects of propofol on NMDA- or nitric oxide-mediated neurotoxicity in vitro. Shibuta S , Sriranganathan V, Inoue T, Shimizu T, Tomi K, Mashimo T. Neuroreport 12(2):295-8. 2001
    8. Neuroprotective effect of hypothermia at defined intraischemic time courses in cortical cultures. Varathan S, Shibuta S, Shimizu T, Mashimo T. J Neurosci Res. 65(6):583-90. 2001
    9. Hypothermia and thiopentone sodium: individual and combined neuroprotective effects on cortical cultures exposed to prolonged hypoxic episodes. Varathan S, Shibuta S, Shimizu T, Varathan V, Mashimo T. J Neurosci Res. 68(3):352-62. 2002
    10. Effects of deep hypothermia on nitric oxide-induced cytotoxicity in primary cultures of cortical neurons. Varathan S, Shibuta S, Varathan V, Takemura M, Yonehara N, Mashimo T. J Neurosci Res. 72(5):613-21. 2003
    11. The neuroprotective effect of ONO-1714 on NMDA-mediated cytotoxicity in vitro. Shibuta S, Varathan S, Mashimo T. J Neurol Sci. 215(1-2):31-6. 2003
    12. Ketamine and thiopental sodium: individual and combined neuroprotective effects on cortical cultures exposed to NMDA or nitric oxide. Shibuta S, Varathan S, Mashimo T. Bri J Anaesth 97 (4): 517‒24. 2006
    13. Small temperature variations alter edaravone-induced neuroprotection of cortical cultures exposed to prolonged hypoxic episodes. S. Shibuta, S. Varathan, T. Kamibayashi, and T. Mashimo. Br. J. Anaesth. 104: 52-58. 2010
    14. Only extra-high dose of Ketamine affects L-glutamate-induced Ca2+ elevation and neurotoxicity. S. Shibuta, T. Morita, J. Kosaka, T. Kamibayashi, and Y. Fujino. Neurosci Res 98:9-16. 2015
    15. Thiopental sodium preserves the responsiveness to glutamate but not acetylcholine in rat primary cultured neurons exposed to hypoxia. Tomotaka Morita, Satoshi Shibuta, Jun Kosaka, Yuji Fujino. Journal of the Neurological Sciences 365: 126–131 2016
    16. Intravenous anesthetic-induced calcium dysregulation and neurotoxic shift with age during development in primary cultured neurons. Satoshi SHIBUTA, Tomotaka MORITA, Jun KOSAKA. Neurotoxicology 69: 320-9 2018
  • 学位・学歴
    • 鳥取大学卒
    • 大阪大学大学院修了、医学博士
  • 職歴・学会
    • 【職歴】

      • 前大阪大学大学院医学系研究科生体統御医学講座麻酔集中治療医学教室講師
    • 【学会】

      • 日本麻酔科学会、日本小児麻酔科学会、日本神経麻酔集中治療学会
      • Society for Neuroscience
    • 【資格】

      • 日本麻酔科学会認定指導医、厚生労働省認定麻酔科標榜医